Article
Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice.
Mechanisms of ageing and development - 1 Mar 2011
He Dongwei, Uehara Yoshihiko, Furuya Maiko, Ikehata Hironobu, Komura Jun-ichiro, Yamauchi Kazumi, Kakinuma Shizuko, Shang Yi, Shimada Yoshiya, Ootsuyama Akira, Norimura Toshiyuki, Ono Tetsuya
Abstract excerpt
To understand the effect of calorie restriction on genome maintenance systems, the age-dependent accumulation of mutations in animals maintained on high and low calorie diets was examined using lacZ-transgenic mice. Mice were fed a diet of 95 kcal/w or 65 kcal/w from 2 to 17 months of age. The mutation frequencies in the lacZ gene in epithelial tissues from the small intestine were examined at 12 and 17 months....
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