Somatic mutations and aging: a re-evaluation.

doi:10.1016/s0027-5107(99)00202-x

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Article

Somatic mutations and aging: a re-evaluation.

Mutation research - 17 Jan 2000

Vijg J

Abstract excerpt

Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation...

Topics

Aging
Aging, Premature
Animals
Biological Evolution
Cell Death
Cell Transformation, Neoplastic
Cellular Senescence
Cytogenetics
DNA Repair
DNA, Mitochondrial
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Knockout
Mice, Transgenic
Mutation

Source

Open in PubMed

Identifiers

PMID: 10686308
DOI: 10.1016/s0027-5107(99)00202-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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