Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential role of PKR in double-stranded RNA-induced macrophage activation.

The EMBO journal - 17 Jul 2000

Maggi L B, Heitmeier M R, Scheuner D, Kaufman R J, Buller R M, Corbett J A

Abstract excerpt

In this study, the role of the double-stranded (ds) RNA-dependent protein kinase (PKR) in macrophage activation was examined. dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to eIF-2 Kinase
Share to Enzyme Induction
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrophage Activation

Share to Macrophages, Peritoneal

Share to Nitric Oxide Synthase Type II

Share to Poly I-C

Share to RNA, Double-Stranded

Source

Open in PubMed Open full text

Identifiers

PMID: 10899117
DOI: 10.1093/emboj/19.14.3630
PMCID: PMC313973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential role of PKR in double-stranded RNA-induced macrophage activation.PMID 10899117Read ↗

The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activationSemantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKRSemantic proximity Read ↗

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.Semantic proximity Read ↗

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.Semantic proximity Read ↗

Double stranded RNA-dependent protein kinase is involved in osteoclast differentiation of RAW264.7 cells in vitro.Semantic proximity Read ↗

Regulation of Macrophage Inflammatory Gene Expression by the Orphan Nuclear Receptor Nur77Semantic proximity Read ↗

Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.Semantic proximity Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells.Semantic proximity Read ↗

Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1.Semantic proximity Read ↗

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.