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Article

Regulation of Macrophage Inflammatory Gene Expression by the Orphan Nuclear Receptor Nur77

9 Dec 2005

Abstract excerpt

Members of the nuclear hormone receptor superfamily have emerged as important regulators of macrophage gene expression in inflammation and disease. Previous studies have shown that the lipid-activated receptors peroxisomal proliferator-activated receptor and liver X receptor inhibit nuclear factor-kappaB (NF-kappaB) signaling and inflammatory gene expression. We recently identified the NR4A subfamily of orphan...

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PMID: 16339277
DOI: 10.1210/me.2005-0331

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