Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1.

Biochimica et biophysica acta - 1 Jul 2016

Köröskényi Krisztina, Kiss Beáta, Szondy Zsuzsa

Abstract excerpt

Adenosine is known to reduce inflammation by suppressing the activity of most immune cells. Previous studies have shown that lipopolysaccharide (LPS) stimulated mouse macrophages produce adenosine, and the adenosine A2A receptor (A2AR) signaling activated in an autocrine manner attenuates LPS-induced pro-inflammatory cytokine formation. It has been suggested that A2AR signaling inhibits LPS-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JNK Mitogen-Activated Protein Kinases

Share to Lipopolysaccharides

Share to NF-kappa B p50 Subunit

Share to Receptor, Adenosine A2A

Share to RNA Interference

Share to Transcription Factor RelA

Source

Identifiers

PMID: 27066978
DOI: 10.1016/j.bbamcr.2016.04.003

Genes

DUSP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1.PMID 27066978Read ↗

New insights into the regulation of inflammation by adenosine.Semantic proximity Read ↗

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage.Semantic proximity Read ↗

Cyclic AMP Regulates Key Features of Macrophages via PKA: Recruitment, Reprogramming and Efferocytosis.Semantic proximity Read ↗

Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.Semantic proximity Read ↗

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.Semantic proximity Read ↗

Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype.Semantic proximity Read ↗

Role and regulation of MKP-1 in airway inflammationSemantic proximity Read ↗

Both Erk and p38 Kinases Are Necessary for Cytokine Gene TranscriptionSemantic proximity Read ↗

Endogenous prostaglandin E2 potentiates anti-inflammatory phenotype of macrophage through the CREB-C/EBP-β cascade.Semantic proximity Read ↗

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.Semantic proximity Read ↗

Proteinase-activated receptor 2 activation promotes an anti-inflammatory and alternatively activated phenotype in LPS-stimulated murine macrophages.Semantic proximity Read ↗

Targeting MAPAKAP2(MK2) to combat inflammation by avoiding the differential regulation of anti-inflammatory genes by p38 MAPK inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.