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Article

A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay.

Chemical research in toxicology - 1 Jul 2000

Peterson L A, Naruko K C, Predecki D P

Abstract excerpt

Furan is classified as a nongenotoxic hepatocarcinogen. It is thought to be activated to a toxic metabolite, cis-2-butene-1,4-dial, which is acutely toxic to liver cells. The resulting cytotoxicity is followed by compensatory cell proliferation, increasing the likelihood of tumor production. We examined the genotoxic activity of cis-2-butene-1,4-dial in several strains of Salmonella typhimurium commonly used in...

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PMID: 10898583
DOI: 10.1021/tx000065f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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