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Article

1,3-Butadiene: II. Genotoxicity profile.

Critical reviews in toxicology - 1 Oct 2010

Albertini Richard J, Carson M Leigh, Kirman Christopher R, Gargas Michael L

Abstract excerpt

1,3-Butadiene’s (BD’s) major electrophilic metabolites 1,2-epoxy-3-butene (EB), 1,2-dihydroxy-3,4-epoxybutane (EBD), and 1,2,3,4-diepoxybutane (DEB) are responsible for both its mutagenicity and carcinogenicity. EB, EBD, and DEB are DNA reactive, forming a variety of adducts. All three metabolites are genotoxic in vitro and in vivo, with relative mutagenic potencies of DEB >> EB > EBD. DEB...

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PMID: 20868267
DOI: 10.3109/10408444.2010.507182

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