Article
1,3-Butadiene: II. Genotoxicity profile.
Critical reviews in toxicology - 1 Oct 2010
Albertini Richard J, Carson M Leigh, Kirman Christopher R, Gargas Michael L
Abstract excerpt
1,3-Butadiene’s (BD’s) major electrophilic metabolites 1,2-epoxy-3-butene (EB), 1,2-dihydroxy-3,4-epoxybutane (EBD), and 1,2,3,4-diepoxybutane (DEB) are responsible for both its mutagenicity and carcinogenicity. EB, EBD, and DEB are DNA reactive, forming a variety of adducts. All three metabolites are genotoxic in vitro and in vivo, with relative mutagenic potencies of DEB >> EB > EBD. DEB...
Topics
- Animals
- Biomarkers
- Butadienes
- Carcinogenicity Tests
- Chromosome Aberrations
- DNA Adducts
- DNA Damage
- Drosophila
- Epoxy Compounds
- Female
- Humans
- Male
- Mice
- Mutation
- Rats