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Article

Stabilization and activation of p53 by the coactivator protein TAFII31.

The Journal of biological chemistry - 27 Apr 2001

Buschmann T, Lin Y, Aithmitti N, Fuchs S Y, Lu H, Resnick-Silverman L, Manfredi J J, Ronai Z, Wu X

Abstract excerpt

Regulation of the stability of p53 is key to its tumor-suppressing activities. mdm2 directly binds to the amino-terminal region of p53 and targets it for degradation through the ubiquitin-proteasome pathway. The coactivator protein TAF(II)31 binds to p53 at the amino-terminal region that is also...

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Source

Identifiers

PMID: 11278372
DOI: 10.1074/jbc.M007955200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11278372-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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