Stable long-term germ-line transmission of transgene integration sites in mice.

doi:10.1023/a:1008824028100

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Article

Stable long-term germ-line transmission of transgene integration sites in mice.

Transgenic research - 1 Feb 1999

Aigner B, Fleischmann M, Müller M, Brem G

Abstract excerpt

Transgenic mice provide a valuable tool in all fields of basic and applied biological and medical research. In this study, we describe the fate of integrated transgenes in the mammalian host genome over a large number of generations. The stability of the germ-line transmission of integrated tyrosinase transgene copies was monitored up to generation F20 in a large number of individuals from seven transgenic mouse...

Topics

Animals
Breeding
Germ Cells
Homozygote
Mice
Mice, Transgenic
Monophenol Monooxygenase
Phenotype
Transgenes

Source

Open in PubMed

Identifiers

PMID: 10399363
DOI: 10.1023/a:1008824028100

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