Article
Non-invasive genotyping of transgenic mice: comparison of different commercial kits and required amounts.
ALTEX - 1 Jan 2010
Hamann Melanie, Lange Nikola, Kuschka Jagoda, Richter Angelika
Abstract excerpt
The usefulness of genetically modified mice is discussed critically. Nevertheless, their number has increased dramatically over the past years. A principle for the use these mice is the isolation of DNA to determine whether an individual carries the genetic modification or not. This "genotyping" is usually done by invasive tissue sampling, e.g. tail biopsies, which likely causes discomfort and pain to the animals...
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