Effects of site-directed mutations of transmembrane cysteines in sindbis virus E1 and E2 glycoproteins on palmitylation and virus replication.

doi:10.1006/viro.1998.9281

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Article

Effects of site-directed mutations of transmembrane cysteines in sindbis virus E1 and E2 glycoproteins on palmitylation and virus replication.

Virology - 15 Sept 1998

Ryan C, Ivanova L, Schlesinger M J

Abstract excerpt

The two glycoproteins that form the external spikes of the alphaviruses are type 1 membrane proteins whose transmembrane domains of hydrophobic amino acids are close to the carboxyl termini of the polypeptides and anchor the proteins in the lipid bilayer. Most of the members of the alphavirus gen...

Topics

Animals
Cell Line
Gene Expression Regulation, Viral
Membrane Glycoproteins
Mutagenesis, Site-Directed
Mutation
Palmitic Acids
Sindbis Virus
Viral Envelope Proteins
Virus Replication

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