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Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivity

9 Oct 2008

Abstract excerpt

The alphavirus Sindbis virus (SINV) causes encephalomyelitis in mice. Lipid-containing membranes, particularly cholesterol and sphingomyelin (SM), play important roles in virus entry, RNA replication, glycoprotein transport, and budding. Levels of SM are regulated by sphingomyelinases (SMases). Acid SMase (ASMase) deficiency results in the lipid storage disease type A Niemann-Pick disease (NPD-A), mimicked in...

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PMID: 18845681
DOI: 10.1073/pnas.0808720105

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