Article
Thymopoiesis and T cell development in common gamma chain-deficient dogs.
Immunologic research - 1 Jan 2003
Felsburg Peter J, Hartnett Brian J, Gouthro Terry A, Henthorn Paula S
Abstract excerpt
Our laboratory has identified an X-linked severe combined immunodeficiency (XSCID) in dogs that is the result of mutations in the common gamma chain (gammac) subunit of the interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. Canine XSCID, unlike genetically engineered gammac-deficient mice, has a clinical and immunologic phenotype virtually identical to human XSCID, suggesting species-specific...
Topics
- Animals
- Cell Differentiation
- Disease Models, Animal
- Dogs
- Humans
- Mutation
- Receptors, Interleukin
- Severe Combined Immunodeficiency
- T-Lymphocytes
- Thymus Gland