Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.

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Article

Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.

Blood - 1 Jan 1995

Matthews D J, Clark P A, Herbert J, Morgan G, Armitage R J, Kinnon C, Minty A, Grabstein K H, Caput D, Ferrara P

Abstract excerpt

The interleukin-2 (IL-2) receptor gamma-chain is a common component of several members of the cytokine receptor superfamily including those for IL-2, IL-4, IL-7, IL-9, IL-15, and possibly IL-13, and has recently been renamed the common gamma-chain (gamma c-chain). Transfection experiments have shown that the gamma c-chain participates in signal transduction by IL-2, IL-4 and IL-7, but a functional role for the...

Topics

B-Lymphocytes
Cell Division
Genetic Linkage
Humans
Immunoglobulin E
Infant
Interleukin-13
Interleukin-15
Interleukin-2
Interleukin-4
Interleukins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Male

Mutation

Polymerase Chain Reaction

Receptors, Interleukin-2

Severe Combined Immunodeficiency

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 7803808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7803808-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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