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Article

The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.

Immunological reviews - 1 Apr 1994

Leonard W J, Noguchi M, Russell S M, McBride O W

Abstract excerpt

X-linked severe combined immunodeficiency is characterized by severe and persistent infections from early life resulting from profound impairment of both cellular and humoral immune function. XSCID is characterized by an absence or diminished number of T cells and histologic evidence of hypoplastic and abnormal differention of the thymic epithelium. The discovery that this disease results from the mutations of...

Topics

Animals
Genetic Linkage
Humans
Mice
Molecular Biology
Mutation
Pedigree
Receptors, Interleukin
Receptors, Interleukin-2
Receptors, Interleukin-4
Receptors, Interleukin-7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Mitogen

Severe Combined Immunodeficiency

X Chromosome

Source

Identifiers

PMID: 8070818
DOI: 10.1111/j.1600-065x.1994.tb00847.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8070818-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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