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Article

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.

The Journal of experimental medicine - 15 Jun 1998

Salomoni P, Wasik M A, Riedel R F, Reiss K, Choi J K, Skorski T, Calabretta B

Abstract excerpt

The oncogenic BCR/ABL protein protects hematopoietic cells from apoptosis induced by growth factor deprivation, but the mechanisms are only partially understood. A BCR/ABL mutant lacking amino acids 176-426 in the BCR domain (p185DeltaBCR) failed to protect interleukin 3-deprived 32Dcl3 myeloid precursor cells from apoptosis, although it possessed tyrosine kinase activity and was capable of activating the...

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Source

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Identifiers

PMID: 9625759
DOI: 10.1084/jem.187.12.1995
PMCID: PMC2212373

Genes

BCR
BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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