Article
Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.
The Journal of experimental medicine - 15 Jun 1998
Salomoni P, Wasik M A, Riedel R F, Reiss K, Choi J K, Skorski T, Calabretta B
Abstract excerpt
The oncogenic BCR/ABL protein protects hematopoietic cells from apoptosis induced by growth factor deprivation, but the mechanisms are only partially understood. A BCR/ABL mutant lacking amino acids 176-426 in the BCR domain (p185DeltaBCR) failed to protect interleukin 3-deprived 32Dcl3 myeloid p...
Topics
- Animals
- Apoptosis
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Compartmentation
- Fusion Proteins, bcr-abl
- Hematopoietic Stem Cells
- Interleukin-3
- Leukemia, Experimental
- Mice
- Mitochondria
- Mutation
- Oncogenes
- Proto-Oncogene Proteins c-raf
- Signal Transduction