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Article

The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2.

Cell death and differentiation - 1 Nov 2002

Adachi M, Imai K

Abstract excerpt

The BH3-only protein BAD binds to Bcl-2 family proteins through its BH3 domain. Recent studies suggest that BAD binds to both Bcl-2 and Bcl-X(L), however mediates its pro-apoptotic functions through inhibition of Bcl-X(L), but not Bcl-2. In this paper we addressed this issue using a BAD mutant within the BH3 domain, by substitution of Asp 119 with Gly (BAD(D119G)), which selectively abrogates an ability to...

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Identifiers

PMID: 12404123
DOI: 10.1038/sj.cdd.4401097

Genes

BAD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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