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Article

The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD.

International journal of cancer - 1 Oct 2006

Schmitz Roland, Thomas Roman K, Harttrampf Anne C, Wickenhauser Claudia, Schultze Joachim L, Hansmann Martin-Leo, Wolf Jürgen, Küppers Ralf

Abstract excerpt

Members of the BCL-2 gene family are well known for their role in the pathogenesis of B-cell lymphomas in humans and in mouse models. A recent report that knockout mice deficient for the proapoptotic BCL-2 family member gene BAD frequently develop B-cell lymphomas prompted us to analyze a large collection of human B-cell lymphomas for inactivating mutations in the BAD gene. All 3 exons of the BAD gene were...

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Identifiers

PMID: 16646081
DOI: 10.1002/ijc.22010

Genes

BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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