Article
Phosphorylation of human p53 on Thr-55.
Biochemistry - 15 Aug 2000
Gatti A, Li H H, Traugh J A, Liu X
Abstract excerpt
The pleiotropic function of p53 is believed to be greatly influenced by phosphorylation, and several sites on p53 are known to be targets for distinct protein kinases. In this study, we observed that affinity-purified p53 from overexpressing cells was phosphorylated by a co-purified protein kinase in vitro. To identify phosphorylation site(s), the resulting phosphorylated p53 protein was subjected to primary and...
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