Article
Structural characterization of the cysteine-rich domain of TFIIH p44 subunit.
The Journal of biological chemistry - 13 Oct 2000
Fribourg S, Kellenberger E, Rogniaux H, Poterszman A, Van Dorsselaer A, Thierry J C, Egly J M, Moras D, Kieffer B
Abstract excerpt
In an effort to understand the structure function relationship of TFIIH, a transcription/repair factor, we focused our attention on the p44 subunit, which plays a central role in both mechanisms. The amino-terminal portion of p44 has been shown to be involved in the regulation of the XPD helicase activity; here we show that its carboxyl-terminal domain is essential for TFIIH transcription activity and that it...
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