Article
The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.
Nucleic acids research - 13 Oct 2017
Radu Laura, Schoenwetter Elisabeth, Braun Cathy, Marcoux Julien, Koelmel Wolfgang, Schmitt Dominik R, Kuper Jochen, Cianférani Sarah, Egly Jean M, Poterszman Arnaud, Kisker Caroline
Abstract excerpt
The general transcription factor IIH (TFIIH) is a multi-protein complex and its 10 subunits are engaged in an intricate protein-protein interaction network critical for the regulation of its transcription and DNA repair activities that are so far little understood on a molecular level. In this study, we focused on the p44 and the p34 subunits, which are central for the structural integrity of core-TFIIH. We...
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