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Article

Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family.

American journal of human genetics - 1 Aug 2000

Greenwood C M, Fujiwara T M, Boothroyd L J, Miller M A, Frappier D, Fanning E A, Schurr E, Morgan K

Abstract excerpt

An epidemic of tuberculosis occurred in a community of Aboriginal Canadians during the period 1987-89. Genetic and epidemiologic data were collected on an extended family from this community, and the evidence for linkage to NRAMP1, a candidate gene for susceptibility to mycobacterial diseases, was assessed. Individuals were grouped into risk (liability) classes based on vaccination, age, previous disease, and...

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Identifiers

PMID: 10882571
DOI: 10.1086/303012
PMCID: PMC1287187

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