Article
An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults.
The Journal of experimental medicine - 10 Jul 2006
Baghdadi Jamila El, Orlova Marianna, Alter Andrea, Ranque Brigitte, Chentoufi Mohamed, Lazrak Faouzia, Archane Moulay Idriss, Casanova Jean-Laurent, Benslimane Abdellah, Schurr Erwin, Abel Laurent
Abstract excerpt
The molecular basis of genetic predisposition to pulmonary tuberculosis in adults remains largely elusive. Few candidate genes have consistently been implicated in tuberculosis susceptibility, and no conclusive linkage was found in two previous genome-wide screens. We report here a genome-wide linkage study in a total sample of 96 Moroccan multiplex families, including 227 siblings with microbiologically and...
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