Article
No evidence for linkage between leprosy susceptibility and the human natural resistance-associated macrophage protein 1 (NRAMP1) gene in French Polynesia.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association - 1 Jun 1997
Roger M, Levee G, Chanteau S, Gicquel B, Schurr E
Abstract excerpt
In order to determine whether a human homolog (NRAMP1) to a murine candidate gene for resistance to mycobacteria influences susceptibility to human disease, we analyzed data from seven multicase leprosy families (84 individuals) from French Polynesia for linkage markers within the NRAMP1 gene and leprosy per se. Individual family members were typed at nine polymorphic loci within NRAMP1. In addition, three...
Topics
- Alleles
- Carrier Proteins
- Cation Transport Proteins
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Leprosy
- Lod Score
- Male
- Membrane Proteins
- Microsatellite Repeats
- Pedigree
- Polymerase Chain Reaction