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Article

Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.

Journal of medical genetics - 1 Aug 1996

Shaw M A, Clayton D, Atkinson S E, Williams H, Miller N, Sibthorpe D, Blackwell J M

Abstract excerpt

The macrophage resistance gene NRAMP1 regulates priming/activation of macrophages for enhanced TNF alpha, IL 1 beta, and MHC class II expression. Since all of these functions are of potential importance in the induction or maintenance or both of autoimmune disease, samples from the Arthritis and...

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Share to Polymorphism, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 8863160
DOI: 10.1136/jmg.33.8.672
PMCID: PMC1050702

Genes

VIL1
DES
TNF
TNP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8863160-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.PMID 8863160Read ↗

Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis.Semantic proximity Read ↗

Linkage and association studies of the natural resistance associated macrophage protein 1 (NRAMP1) locus in rheumatoid arthritis.Semantic proximity Read ↗

Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis.Semantic proximity Read ↗

Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family.Semantic proximity Read ↗

Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region.Semantic proximity Read ↗

Susceptibility to leprosy is linked to the human NRAMP1 gene.Semantic proximity Read ↗

Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families.Semantic proximity Read ↗

Extent and distribution of linkage disequilibrium around the SLC11A1 locus.Semantic proximity Read ↗

Investigation of candidate disease susceptibility genes in rheumatoid arthritis: principles and strategies.Semantic proximity Read ↗

Analysis of the MHC-encoded transporters TAP1 and TAP2 in rheumatoid arthritis: linkage with DR4 accounts for the association with a minor TAP2 allele.Semantic proximity Read ↗

Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom.Semantic proximity Read ↗

NRAMP1 gene polymorphisms in patients with rheumatoid arthritis.Semantic proximity Read ↗

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