Article
Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.
American journal of human genetics - 1 Sept 2004
Cheng Li Shu-Chuan, Chiang Shang-Lun, Tu Hung-Pin, Chang Shun-Jen, Wang Tsu-Nai, Ko Allen Min-Jen, Chakraborty Ranajit, Ko Ying-Chin
Abstract excerpt
Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region. We report here a genomewide linkage study of 21 multiplex pedigrees with gout from an aboriginal tribe in Taiwan. From observations of familial clustering, early onset of gout, and...
Topics
- Adult
- Chromosomes, Human, Pair 4
- Family Health
- Founder Effect
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genome, Human
- Gout
- Humans
- Hyperuricemia
- Lod Score
- Middle Aged
- Models, Genetic