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Article

A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span.

Genetics - 1 Dec 2002

Newman Brenda L, Lundblad James R, Chen Yang, Smolik Sarah M

Abstract excerpt

Control of chromosome structure is important in the regulation of gene expression, recombination, DNA repair, and chromosome stability. In a two-hybrid screen for proteins that interact with the Drosophila CREB-binding protein (dCBP), a known histone acetyltransferase and transcriptional coactivator, we identified the Drosophila homolog of a yeast chromatin regulator, Sir2. In yeast, Sir2 silences genes via an...

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Identifiers

PMID: 12524341
DOI: 10.1093/genetics/162.4.1675
PMCID: PMC1462366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span.PMID 12524341Read ↗

The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation.Semantic proximity Read ↗

The Sir2 Family of Protein DeacetylasesSemantic proximity Read ↗

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination.Semantic proximity Read ↗

SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.Semantic proximity Read ↗

Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity.Semantic proximity Read ↗

The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.Semantic proximity Read ↗

The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.Semantic proximity Read ↗

The BAH domain of Rsc2 is a histone H3 binding domain.Semantic proximity Read ↗

A single H2A variant prevents genome instability through piRNAs biogenesis and replication stress control.Semantic proximity Read ↗

Key functional regions in the histone variant H2A.Z C-terminal docking domain.Semantic proximity Read ↗

UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

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