Article
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Pancreas - 1 Jul 2000
Matsubayashi H, Watanabe H, Ajioka Y, Nishikura K, Yamano M, Seki T, Saito T, Matsubayashi T
Abstract excerpt
Clinically, differential diagnosis of pancreatic carcinoma (PC) and so-called "mass-forming pancreatitis (MFP)" is difficult. We analyzed the amount, ductal level, and K-ras mutation of ductal hyperplasia and intraductal carcinoma in surgically resected cases of MFP (n = 18) and PC (n = 16). DNAs extracted from microdissected epithelial foci were analyzed for K-ras codon 12 mutation by nested polymerase chain...
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