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Article

Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.

Oncogene - 20 Jun 2002

Laghi Luigi, Orbetegli Ombretta, Bianchi Paolo, Zerbi Alessandro, Di Carlo Valerio, Boland C Richard, Malesci Alberto

Abstract excerpt

Recent studies on small series of pancreatic cancer (PC) with foci of pancreatic intraepithelial neoplasia (PanIN), a putative precursor lesion, have shown that multiple K-RAS mutations may coexist in the same neoplastic pancreas. To see whether mutant-K-RAS polyclonality is a common and specific feature of pancreatic carcinogenesis, we investigated a unselected series of periampullary cancers (41 pancreatic, 13...

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PMID: 12082617
DOI: 10.1038/sj.onc.1205533

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PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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