Article
Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms.
Journal of hepato-biliary-pancreatic surgery - 1 Jan 2008
Kobayashi Noritoshi, Inamori Masahiko, Fujita Koji, Fujisawa Toshio, Fujisawa Nobutaka, Takahashi Hirokazu, Yoneda Masato, Abe Yasunobu, Kawamura Harunobu, Shimamura Takeshi, Kirikoshi Hiroyuki, Kubota Kensuke, Sakaguchi Takashi, Saito Satoru, Saubermann Lawrence J, Nakajima Atsushi
Abstract excerpt
BACKGROUND/PURPOSE: Intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas have a favorable prognosis. However, invasive ductal carcinomas of the pancreas show a rapid progression. The aim of this study was to investigate gene mutations in pure pancreatic juice from IPMN patients and to define these genetic mutations in relation to the histopathological and clinical features of IPMNs. METHODS:...
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