Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of PTEN mutations in metastatic melanoma specimens.

Journal of medical genetics - 1 Sept 2000

Celebi J T, Shendrik I, Silvers D N, Peacocke M

Abstract excerpt

CONTEXT: PTEN, a tumour suppressor gene located on chromosome 10q23, develops somatic mutations in various tumours and tumour cell lines including brain, endometrium, prostate, breast, kidney, thyroid, liver, and melanoma. OBJECTIVES: To investigate the mutational profile of this gene further, as well as its role in tumour progression in melanoma. DESIGN, SETTINGS: We examined 21 metastatic melanoma samples for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 10
Share to Genes, p16
Share to Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Neoplasm Metastasis

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10978354
DOI: 10.1136/jmg.37.9.653
PMCID: PMC1734683

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of PTEN mutations in metastatic melanoma specimens.PMID 10978354Read ↗

Genetic alterations of PTEN in human melanoma.Semantic proximity Read ↗

Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas.Semantic proximity Read ↗

PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell linesSemantic proximity Read ↗

PTEN/MMAC1 in malignant melanoma and its importance for tumor progression.Semantic proximity Read ↗

Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations.Semantic proximity Read ↗

Clinical relevance of SKP2 alterations in metastatic melanoma.Semantic proximity Read ↗

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation.Semantic proximity Read ↗

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.Semantic proximity Read ↗

PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.Semantic proximity Read ↗

PTEN/MMAC1 expression in melanoma resection specimens.Semantic proximity Read ↗

PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo.Semantic proximity Read ↗

High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.