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Article

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.

Nature structural biology - 1 Jun 2000

Savvides S N, Boone T, Andrew Karplus P

Abstract excerpt

Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell...

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Source

Identifiers

PMID: 10881197
DOI: 10.1038/75896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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