Article
Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.
Nature - 14 Apr 1994
Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan J F, Kastelein R, Hudak S, Wagner J, Mattson J
Abstract excerpt
The FLT3/FLK2 receptor tyrosine kinase is closely related to two receptors, c-Kit and c-Fms, which function with their respective ligands, Kit ligand and macrophage colony-stimulating factor to control differentiation of haematopoietic and non-haematopoietic cells. FLT3/FLK2 is thought to be pres...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Culture Media, Conditioned
- DNA, Complementary
- Genetic Variation
- Hematopoietic Stem Cells
- Humans
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Proto-Oncogene Proteins
- RNA, Messenger