Article
FLT3: receptor and ligand.
Growth factors (Chur, Switzerland) - 1 Jun 2004
Drexler Hans G, Quentmeier Hilmar
Abstract excerpt
FLT3 is a receptor tyrosine kinase (RTK) expressed by immature hematopoietic progenitor cells. The ligand for FLT3 is a transmembrane or soluble protein and is expressed by a variety of cells including hematopoietic and marrow stromal cells; in combination with other growth factors, the ligand stimulates proliferation and development of stem cells, myeloid and lymphoid progenitor cells, dendritic cells and...
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