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Article

Two genetically separable steps in the differentiation of thymic epithelium.

Science (New York, N.Y.) - 10 May 1996

Nehls M, Kyewski B, Messerle M, Waldschütz R, Schüddekopf K, Smith A J, Boehm T

Abstract excerpt

The development of the thymus depends initially on epithelial-mesenchymal and subsequently on reciprocal lympho-stromal interactions. The genetic steps governing development and differentiation of the thymic microenvironment are unknown. With the use of a targeted disruption of the whn gene, which recapitulates the phenotype of the athymic nude mouse, the WHN transcription factor was shown to be the product of...

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Identifiers

PMID: 8629026
DOI: 10.1126/science.272.5263.886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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