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Article

Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1.

Molecular and cellular biology - 1 Aug 2003

Lee Hee Chul, Hon Thomas, Lan Changgui, Zhang Li

Abstract excerpt

Heme-responsive motifs (HRMs) mediate heme regulation of diverse regulatory proteins. The heme activator protein Hap1 contains seven HRMs, but only one of them, HRM7, is essential for heme activation of Hap1. To better understand the molecular basis underlying the biological significance of HRMs,...

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Identifiers

PMID: 12897155
DOI: 10.1128/MCB.23.16.5857-5866.2003
PMCID: PMC166322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12897155-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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