Article
A microarray-assisted screen for potential Hap1 and Rox1 target genes in Saccharomyces cerevisiae.
Yeast (Chichester, England) - 1 Jul 2002
Ter Linde José J M, Steensma H Yde
Abstract excerpt
Saccharomyces cerevisiae adapts to altered oxygen availability by differentially expressing a number of genes. Under aerobic conditions oxygen control of gene expression is exerted through the activator Hap1 and the repressor Rox1. The Hap1 transcription factor senses cellular heme status and increases expression of aerobic genes in response to oxygen. The repression of hypoxic genes under normoxic conditions...
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