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Article

Yap7 is a transcriptional repressor of nitric oxide oxidase in yeasts, which arose from neofunctionalization after whole genome duplication.

Molecular microbiology - 1 Jun 2015

Merhej Jawad, Delaveau Thierry, Guitard Juliette, Palancade Benoit, Hennequin Christophe, Garcia Mathilde, Lelandais Gaëlle, Devaux Frédéric

Abstract excerpt

Flavohemoglobins are the main detoxifiers of nitric oxide (NO) in bacteria and fungi and are induced in response to nitrosative stress. In fungi, the flavohemoglobin encoding gene YHB1 is positively regulated by transcription factors which are activated upon NO exposure. In this study, we show that in the model yeast Saccharomyces cerevisiae and in the human pathogen Candida glabrata, the transcription factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25732006
DOI: 10.1111/mmi.12983

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