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Synthetic Hammerhead Ribozymes as Therapeutic Tools to Control Disease Genes

1 Feb 2005

Abstract excerpt

Ribozymes are RNA molecules that have the ability to catalyse the cleavage and formation of covalent bonds in RNA strands at specific sites. The "hammerhead" motif, approximately 30-nucleotide long, is the smallest endonucleolytic cis-acting ribozyme structure found in natural circular RNAs of some plant viroids. Hammerhead ribozymes became appealing when it was shown that it is possible to produce trans-acting...

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PMID: 15638708
DOI: 10.2174/1566523052997541

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