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Preparations of hammerhead ribozymes for investigations of their cleavable sequences.

Nucleic acids symposium series (2004) - 1 Jan 2009

Tateoka Hisaaki, Kawahara Ikumi, Hasegawa Satomi, Haruta Kaichiro, Kondo Yoshinori, Kojima Chojiro, Tanaka Yoshiyuki

Abstract excerpt

Recently, in hammerhead ribozymes, newly identified loop-loop interaction was found to be important for their activation. Therefore, we chemically synthesized a hammerhead ribozyme with this extra loop sequences and its mutant ribozymes, as well as their substrate RNA strands in order to clarify their cleavable sequences. After purification with an anion exchange column chromatography, we were able to obtain...

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PMID: 19749368
DOI: 10.1093/nass/nrp139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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