Article
No difference in expression of chromosomal fragile sites in patients with solid malignant tumours and normal controls.
Genes, chromosomes & cancer - 1 May 1990
Kampmann T, Schmidt A, Rüdiger H W, Tan T L, Pasarge E
Abstract excerpt
The frequency and distribution of rare and common chromosomal fragile sites in metaphases derived from peripheral lymphocytes were compared in 26 patients with malignant solid tumours and 24 normal controls. In order to avoid bias in evaluation, the identity of each individual as patient or control was disclosed only after the study was completed. Rare heritable folic acid inducible fragile sites were found in...
Topics
- Chromosome Fragile Sites
- Chromosome Fragility
- Chromosomes, Human
- Folic Acid
- Genetic Predisposition to Disease
- Humans
- Lymphocytes
- Neoplasms
- Single-Blind Method