Article
Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer.
Cancer research - 15 Jun 2000
Ahrendt S A, Chow J T, Yang S C, Wu L, Zhang M J, Jen J, Sidransky D
Abstract excerpt
Epidemiological studies have demonstrated a strong association between tobacco use and lung cancer; however, the genetic targets of these carcinogens and the role of other environmental agents in this process have yet to be defined. We examined the contribution of alcohol use and cigarette smoking top53 gene mutations in patients with non-small cell lung cancer. Mutations of the p53 gene were detected by sequence...
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