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Article

A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients.

Journal of surgical oncology - 1 Jan 1996

Kondo K, Tsuzuki H, Sasa M, Sumitomo M, Uyama T, Monden Y

Abstract excerpt

Mutations of the p53 tumor suppressor gene are frequent in lung cancers. It is suggested that p53 mutations are associated with smoking-induced lung carcinogenesis. We examined p53 mutations in 53 lung cancers by analyzing reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) to ascertain the association between p53 mutations and smoking. Twenty-five (47%) of 53...

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Identifiers

PMID: 8544455
DOI: 10.1002/(SICI)1096-9098(199601)61:1<20::AID-JSO6>3.0.CO;2-U

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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