Article
A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients.
Journal of surgical oncology - 1 Jan 1996
Kondo K, Tsuzuki H, Sasa M, Sumitomo M, Uyama T, Monden Y
Abstract excerpt
Mutations of the p53 tumor suppressor gene are frequent in lung cancers. It is suggested that p53 mutations are associated with smoking-induced lung carcinogenesis. We examined p53 mutations in 53 lung cancers by analyzing reverse transcription-polymerase chain reaction-single strand conformation...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Carcinoma, Squamous Cell
- Female
- Genes, p53
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Smoking
- Survival Rate