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Article

Ventricular expression of tbx5 inhibits normal heart chamber development.

Developmental biology - 1 Jul 2000

Liberatore C M, Searcy-Schrick R D, Yutzey K E

Abstract excerpt

The T-box gene tbx5 is expressed in the developing heart, forelimb, eye, and liver in vertebrate embryos during critical stages of morphogenesis and patterning. In humans, mutations in the TBX5 gene have been associated with Holt-Oram syndrome, which is characterized by developmental anomalies in...

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Source

Identifiers

PMID: 10864469
DOI: 10.1006/dbio.2000.9748

Genes

GATA4
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-10864469-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Ventricular expression of tbx5 inhibits normal heart chamber development.PMID 10864469Read ↗

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.Semantic proximity Read ↗

Tbx5 is essential for heart development.Semantic proximity Read ↗

Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.Semantic proximity Read ↗

<i>Tbx5</i>specifies the left/right ventricles and ventricular septum position during cardiogenesisSemantic proximity Read ↗

Identification and localization of TBX5 transcription factor during human cardiac morphogenesisSemantic proximity Read ↗

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.Semantic proximity Read ↗

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.Semantic proximity Read ↗

TBX5 is required for embryonic cardiac cell cycle progressionSemantic proximity Read ↗

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.Semantic proximity Read ↗

T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersSemantic proximity Read ↗

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.Semantic proximity Read ↗

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