Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and localization of TBX5 transcription factor during human cardiac morphogenesis

1 Jan 2000

Abstract excerpt

Mutations in the TBX5 transcription factor gene cause human cardiac malformation in Holt-Oram syndrome. To identify and localize TBX5 during cardiac morphogenesis, we performed immunohistochemical studies of TBX5 protein cardiac expression during human embryogenesis. Specific antibody to human TBX5 was generated in rabbits with a TBX5 synthetic peptide and affinity purification of antiserum. Anti-TBX5 was used in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Congenital Heart Disease Studies
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10974675
DOI: 10.1002/1097-0177(200009)219:1<90::aid-dvdy1033>3.0.co;2-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and localization of TBX5 transcription factor during human cardiac morphogenesisPMID 10974675Read ↗

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.Semantic proximity Read ↗

Tbx5 is essential for heart development.Semantic proximity Read ↗

Differential regulation of Tbx5 protein expression and sub-cellular localization during heart developmentSemantic proximity Read ↗

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction systemSemantic proximity Read ↗

Microarray analysis of Tbx5-induced genes expressed in the developing heart.Semantic proximity Read ↗

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome.Semantic proximity Read ↗

Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function.Semantic proximity Read ↗

Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation.Semantic proximity Read ↗

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and DiseaseSemantic proximity Read ↗

Ventricular expression of tbx5 inhibits normal heart chamber development.Semantic proximity Read ↗

Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.Semantic proximity Read ↗

TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.