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Article

Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.

Developmental cell - 14 Aug 2012

Xie Linglin, Hoffmann Andrew D, Burnicka-Turek Ozanna, Friedland-Little Joshua M, Zhang Ke, Moskowitz Ivan P

Abstract excerpt

The developmental mechanisms underlying human congenital heart disease (CHD) are poorly understood. Atrial septal defects (ASDs) can result from haploinsufficiency of cardiogenic transcription factors including TBX5. We demonstrated that Tbx5 is required in the second heart field (SHF) for atrial septation in mice. Conditional Tbx5 haploinsufficiency in the SHF but not the myocardium or endocardium caused ASDs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Gene Expression Regulation, Developmental

Share to Hedgehog Proteins

Share to Neovascularization, Physiologic

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Source

Open in PubMed Open full text

Identifiers

PMID: 22898775
DOI: 10.1016/j.devcel.2012.06.006
PMCID: PMC3912192

Genes

SHF
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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