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Article

Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast.

International journal of cancer - 1 May 2001

Droufakou S, Deshmane V, Roylance R, Hanby A, Tomlinson I, Hart I R

Abstract excerpt

The cell-cell adhesion receptor gene E-cadherin (CDH1) is expressed by epithelial cells, in which it mediates adhesion and morphogenesis. Invasive lobular carcinoma (ILC) characteristically infiltrates diffusely as single cells; by immunohistochemistry, many of these tumours lack E-cadherin expression. In the present study we investigated various ways in which loss of function of the E-cadherin gene could occur...

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Topics

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Share to Breast Neoplasms
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Share to Carcinoma, Lobular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Gene Silencing

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Share to Loss of Heterozygosity

Source

Identifiers

PMID: 11291078
DOI: 10.1002/ijc.1208

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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