Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2005

Mastracci Teresa L, Tjan Suzanna, Bane Anita L, O'Malley Frances P, Andrulis Irene L

Abstract excerpt

Tumor development from an early lesion through to invasive disease is not a clearly defined progression in the breast. Studies of invasive lobular carcinoma have reported mutations, loss of heterozygosity (LOH) and loss of protein expression in epithelial (E)-cadherin, a protein involved in cell adhesion. Our study examines in situ lobular neoplastic lesions without concurrent invasive carcinoma for E-cadherin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha Catenin
Share to beta Catenin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma in Situ

Share to Carcinoma, Lobular

Share to Catenins

Share to Cell Adhesion Molecules

Share to Delta Catenin

Share to Hyperplasia

Source

Identifiers

PMID: 15696125
DOI: 10.1038/modpathol.3800362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast.PMID 15696125Read ↗

Altered expression of E-cadherin in breast cancer. patterns, mechanisms and clinical significance.Semantic proximity Read ↗

Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants.Semantic proximity Read ↗

The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesionsSemantic proximity Read ↗

Molecular drivers of lobular carcinoma in situ.Semantic proximity Read ↗

Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability.Semantic proximity Read ↗

Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type (?clinging ductal carcinoma in situ?)Semantic proximity Read ↗

Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer.Semantic proximity Read ↗

Detection of allelic imbalance indicates that a proportion of mammary hyperplasia of usual type are clonal, neoplastic proliferations.Semantic proximity Read ↗

Biomarker profile and genetic abnormalities in lobular carcinoma in situ.Semantic proximity Read ↗

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression.Semantic proximity Read ↗

Accumulation of Chromosomal Imbalances From Intraductal Proliferative Lesions to Adjacent In Situ and Invasive Ductal Breast CancerSemantic proximity Read ↗

Columnar Cell Lesions of the Breast: The Missing Link in Breast Cancer Progression?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.