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Article

Smooth-muscle contraction without smooth-muscle myosin.

Nature cell biology - 1 Jun 2000

Morano I, Chai G X, Baltas L G, Lamounier-Zepter V, Lutsch G, Kott M, Haase H, Bader M

Abstract excerpt

Here we have used gene-targeting to eliminate expression of smooth-muscle myosin heavy chain. Elimination of this gene does not affect expression of non-muscle myosin heavy chain, and knockout individuals typically survive for three days. Prolonged activation, by KCl depolarisation, of intact bladder preparations from wild-type neonatal mice produces an initial transient state (phase 1) of high force generation...

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Source

Identifiers

PMID: 10854329
DOI: 10.1038/35014065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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