Article
Distinct contractile systems for electromechanical and pharmacomechanical coupling in smooth muscle.
Advances in experimental medicine and biology - 1 Jan 2003
Lamounier-Zepter Valéria, Baltas Leonidas G, Morano Ingo
Abstract excerpt
Electromechanical coupling by KCl depolarization of bladder preparations elicits an initial phasic and subsequent tonic contraction. Using a smooth-muscle myosin heavy chain (SM-MyHC) knock-out mouse model we could previously demonstrate, that phasic and tonic contraction of intact neonatal bladder preparations could be elicited through the recruitment of SM-MyHC and non-muscle myosin heavy chains (NM-MyHC),...
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